4-甲基-[2-(2-三苯甲游基-2H-四唑-5-基)]联苯合成路线 （共 19 条）
反应条件
magnesium; Zinc chloride in tetrahydrofuran; dichlorobis(triphenylphosphine)nickel (II); diethyl ether; water
参考文献
Synthelabo
Patent: US5371233 A1, 1994 ;
反应条件
sodium hydroxide in toluene T=20°C; 3 h;
参考文献
Chao, Shu-Jun; Hui, Xin-Ping; Li, Shuo; Qiu, Zao-Zao; Xu, Peng-Fei; Zhang, Zi-Yi; Wang, Qin; Guan, Zuo-Wu
Journal of the Chinese Chemical Society, 2005 , vol. 52, # 3 p. 539 - 544
反应条件
1H-tetrazole; n-butyllithium; lithium; sodium hydrogencarbonate; sodium chloride; Zinc chloride; nickel in tetrahydrofuran; cyclohexane
参考文献
Merck and Co., Inc.
Patent: US5039814 A1, 1991 ;
反应条件
1.1: zinc chloride; sodium azide / dimethylformamide / 36 h / Heating 1.2: 96 percent / aq. HCl / dimethylformamide / 1 h / cooling 2.1: 91 percent / aq. NaOH / toluene / 3 h / 20 °C View Scheme
参考文献
Huang, Horng-Chih; Reitz, David B.; Chamberlain, Timothy S.; Olins, Gillian M.; Corpus. Valerie M.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2172 - 2181
反应条件
2: 1.) Me3SnN3, 2.) aq. HCl / 1.) toluene, reflux, 24 h, 2.) 25 deg C 3: Et3N / CH2Cl2 / 1.5 h / Heating View Scheme
参考文献
Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2919 - 2922
反应条件
2: 1.) Me3SnN3, 2.) aq. HCl / 1.) toluene, reflux, 24 h, 2.) 25 deg C 3: Et3N / CH2Cl2 / 1.5 h / Heating View Scheme
参考文献
Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2919 - 2922
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 3: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 4: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 6: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 5: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
