反应条件
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 - -10 °C / |Inert atmosphere 1.2: 5 h / -78 - 20 °C / |Inert atmosphere 2.1: toluene / 20 °C 3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 4 h / 100 °C / |Inert atmosphere 4.1: trimethylsilylazide; trifluoroacetic acid / 36 h / 120 °C / |Sealed tube 5.1: triethylamine / dichloromethane / 1 h / 20 °C View Scheme
参考文献
Agelis, George; Resvani, Amalia; Matsoukas, John; Durdagi, Serdar; Spyridaki, Katerina; Liapakis, George; Tumova, Tereza; Slaninova, Jirina; Giannopoulos, Panagiotis; Mavromoustakos, Thomas; Vlahakos, Demetrios
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 358 - 374,17
Title/Abstract Full Text Show Details
Agelis, George; Resvani, Amalia; Durdagi, Serdar; Spyridaki, Katerina; Tumova, Tereza; Slaninova, Jirina; Giannopoulos, Panagiotis; Vlahakos, Demetrios; Liapakis, George; Mavromoustakos, Thomas; Matsoukas, John
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 358 - 374