1-(alpha-氯苄基)-4-溴苯合成路线 （共 8 条）
反应条件
thionyl chloride in dichloromethane T=25°C; Chlorination; 1 h;
参考文献
Plobeck; Delorme; Wei; Yang; Zhou; Schwarz; Gawell; Gagnon; Pelcman; Schmidt; Yue; Walpole; Brown; Labare; Payza; St-Ogne; Kamassah; Morin; Projean; Ducharme; Roberts
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3878 - 3894
反应条件
1: NaBH4 / propan-2-ol 2: HCl, Drierite / CH2Cl2 View Scheme
参考文献
Nishida,S.
Journal of Organic Chemistry, 1967 , vol. 32, p. 2692 - 2695
反应条件
1: tetrahydrofuran / 1 h / 20 °C 2: SOCl2 / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
1: tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere 2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
dihydrogen peroxide; potassium bromide in ethanol 2.5 h; Heating;
参考文献
Tang, Jingting; Zhu, Jinlong; Shen, Zongxuan; Zhang, Yawen
Tetrahedron Letters, 2007 , vol. 48, # 11 p. 1919 - 1921
反应条件
water; acetone T=25°C; Kinetics; Further Variations:Reagents;
参考文献
Denegri, Bernard; Streiter, Andre; Juric, Sandra; Ofial, Armin R.; Kronja, Olga; Mayr, Herbert
Chemistry - A European Journal, 2006 , vol. 12, # 6 p. 1648 - 1656
反应条件
1.1: NaH; NaI / dimethylformamide
1.2: dimethylformamide / 38 h / 60 - 90 °C
2.1: aq. KOH / ethanol / 12 h / Heating
3.1: 0.17 h / 180 °C
View Scheme
参考文献
Elz, Sigurd; Kramer, Kai; Leschke, Christian; Schunack, Walter
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 41 - 52
反应条件
1: titanium tetrachloride / dichloromethane / 2 h / 0 °C / |Inert atmosphere
2: water; sulfuric acid / 0 °C / |Inert atmosphere; |Reflux
3: sulfuric acid / 4 h / 0 °C / |Reflux
View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
