4-(羟基苯基甲基)苯甲腈合成路线 （共 16 条）
反应条件
palladium diacetate; caesium carbonate; triphenylphosphine in chloroform; toluene T=60°C; 24 h;
参考文献
Kuriyama, Masami; Shimazawa, Rumiko; Shirai, Ryuichi
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1597 - 1600
反应条件
1: para-bromobenzonitrile With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 2 h; 2: benzaldehyde in tetrahydrofuran T=0°C; Grignard reaction; 0.333333 h;
参考文献
Ludwig-Maximilians-Universitaet Muenchen
Patent: EP1582523 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate in water T=110°C; Grignard-type carbonyl phenylation; 12 h;
参考文献
Li, Chao-Jun; Meng, Yue
Journal of the American Chemical Society, 2000 , vol. 122, # 39 p. 9538 - 9539
反应条件
tetrabutyl ammonium fluoride in acetonitrile T=120°C; 0.5 h; microwave irradiation;
参考文献
Lerebours, Rachel; Wolf, Christian
Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13052 - 13053
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [rhodium(I)(carbonyl)2(acetylacetonate)] in ethylene glycol dimethyl ether; water T=80°C; 24 h;
参考文献
Pourbaix, Christelle; Carreaux, Francois; Carboni, Bertrand
Organic Letters, 2001 , vol. 3, # 6 p. 803 - 805
反应条件
1: With [2,2']bipyridinyl; sodium acetate; copper(l) chloride in toluene T=110°C; 6 h; 2: With hydrogenchloride in water; toluene
参考文献
Liao, Yuan-Xi; Hu, Qiao-Sheng
Journal of Organic Chemistry, 2011 , vol. 76, # 18 p. 7602 - 7607
反应条件
triethylamine; cadmium(II) sulphide in methanol 3 h; Irradiationother catalyst: CdS-Ald; Mechanism;
参考文献
Shiragami, Tsutomu; Pac, Chyongjin; Yanagida, Shozo
Journal of Physical Chemistry, 1990 , vol. 94, # 2 p. 504 - 506
反应条件
sodium hydroxide; Rhodium trichloride; t-Bu-Amphos in acetonitrile T=80°C; 2 h;
参考文献
Huang, Rongcai; Shaughnessy, Kevin H.
Chemical Communications, 2005 , # 35 p. 4484 - 4486
反应条件
[iridium(III)(2-phenylpyridine)3]; dipotassium hydrogenphosphate; Caprylic Aldehyde; 2-mercaptoacetic acid methyl ester in N,N-dimethyl acetamide T=-78 - 23°C; 12 h; IrradiationInert atmosphere;
参考文献
Qvortrup, Katrine; Rankic, Danica A.; MacMillan, David W.C.
Journal of the American Chemical Society, 2014 , vol. 136, # 2 p. 626 - 629
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.208333 h; Inert atmosphere; chemoselective reaction;
参考文献
Riva; Gagliardi; Martinelli; Passarella; Vigo; Rencurosi
Tetrahedron, 2010 , vol. 66, # 17 p. 3242 - 3247
