反应条件
1.1: water; Aliquatreg; 336 / toluene / 20 °C / Large scale reaction 1.2: 5 h / 50 °C / Large scale reaction 2.1: thionyl chloride / toluene / 1 h / 85 - 90 °C / Large scale reaction 3.1: toluene / 3 h / 80 °C / Large scale reaction 3.2: pH 1 / Large scale reaction 4.1: water / toluene 5.1: sodium methylate / toluene / 10 - 15 °C / Inert atmosphere; Large scale reaction 5.2: 2 h / 50 - 60 °C / Large scale reaction 6.1: water; sodium hydroxide / 3 h / Reflux; Large scale reaction View Scheme
参考文献
Reiter, Jozsef; Trinka, Peter; Bartha, Ferenc L.; Pongo, Laszlo; Volk, Balazs; Simig, Gyula
Organic Process Research and Development, 2012 , vol. 16, # 7 p. 1279 - 1282
