3-(S)-(1-氨基甲酰-1,1-二苯基甲基)吡咯烷合成路线 （共 7 条）
反应条件
sulfuric acid in water T=85 - 90°C; 14 h;
参考文献
MEDICHEM, S.A.
Patent: WO2009/153649 A1, 2009 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With sulfuric acid T=110°C; 2: With sodium hydroxide in water T=30°C; pH=10 - 12;
参考文献
WO2010/32225 A2, ;
Page/Page column 23-24 ;
反应条件
sulfuric acid; sodium hydroxide in dichloromethane; water T=50 - 105°C; pH=10 - 12;
参考文献
WO2009/125430 A2, ;
Page/Page column 7; 11 ;
反应条件
1: With potassium hydroxide; methyltriethyl ammonium chloride in water; butanone T=75°C; 6 h; Heating / reflux; 2: With hydrogen bromide in water; butanone
参考文献
Medichem, S.A.
Patent: US2008/312455 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
1: UK-88862 With sodium hydroxide; water in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride With triethylamine T=95°C; 15 h; 3: With hydrogen bromide in water; acetone 1 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/100651 A2, 2008 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1.1: ethanol / 1 h 2.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 2.2: 12 h / 25 - 75 °C 3.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme
参考文献
Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Tripathy, Narendra K.; Gurjar, Mukund K.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1591 - 1597
反应条件
potassium carbonate in acetonitrile 2 h; Heating / reflux;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/5431 A1, 2009 ;
Location in patent: Page/Page column 33 ;
US 20090005431 A1
