(Z)-3,4,5,4’-四甲氧基二苯乙烯合成路线 （共 18 条）
反应条件
1: 78 percent / m-chloroperoxybenzoic acid; NaHCO3 / CH2Cl2 / 12 h / 20 °C 2: water; potassium hydroxide; carbon tetrachloride / 2-methyl-propan-2-ol / 12 °C / Heating View Scheme
参考文献
Robinson, James E.; Taylor, Richard J. K.
Chemical Communications, 2007 , # 16 p. 1617 - 1619
反应条件
1: 73 percent / potassium hydroxide / ethanol / 12 h / 0 - 25 °C 2: 78 percent / m-chloroperoxybenzoic acid; NaHCO3 / CH2Cl2 / 12 h / 20 °C 3: water; potassium hydroxide; carbon tetrachloride / 2-methyl-propan-2-ol / 12 °C / Heating View Scheme
参考文献
Robinson, James E.; Taylor, Richard J. K.
Chemical Communications, 2007 , # 16 p. 1617 - 1619
反应条件
1: 3,4,5-Trimethoxybenzyltriphenylphosphonium Bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: (4-methoxyphenyl)methanol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 12 h; Inert atmosphereReflux; optical yield given as percent de;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
1: 5-(chloromethyl)-1,2,3-trimethoxybenzene With tributylphosphine in tetrahydrofuran T=0°C; Wittig reaction; 0.0833333 h; 2: 4-methoxy-benzaldehyde With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; Wittig reaction; 16 h; optical yield given as percent dediastereoselective reaction;
参考文献
Fumagalli, Tiziano; Sello, Guido; Orsini, Fulvia
Synthetic Communications, 2009 , vol. 39, # 12 p. 2178 - 2195
反应条件
1: 95 percent / phosphorus tribromide / CH2Cl2 / 12 h / 0 °C 2: toluene / 6 h / Heating 3: 0.8 g / n-butyllithium / hexane; tetrahydrofuran / 16 h / -78 °C View Scheme
参考文献
Zhang; Go
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 6 p. 841 - 850
反应条件
nickel in tetrahydrofuran Wittig type olefination; 12 h; Reflux; optical yield given as percent de;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
Tetrahedron Letters, 2009 , vol. 50, # 25 p. 3070 - 3073
反应条件
1: triethylamine; acetic anhydride / 3 h / |Reflux 2: copper; quinoline / 2 h / 200 °C View Scheme
参考文献
Liu, Ying-Qian; Li, Xiao-Jing; Zhao, Chun-Yan; Lu, Yan; Li, Wen-Qun; Liu, Zhen-Ling; Feng, Gang; Yang, Liu
Medicinal Chemistry Research, 2013 , vol. 22, # 5 p. 2196 - 2206
反应条件
1: 28 percent / KMnO4; Ac2O / 1 h / 0 - 20 °C 2: 95 percent / hydroxylamine hydrochloride; pyridine / ethanol / 72 h / 90 °C 3: 34 percent / DIAD; PPh3 / toluene / 1 h / Heating View Scheme
参考文献
Tron, Gian Cesare; Pagliai, Francesca; Del Grosso, Erika; Genazzani, Armando A.; Sorba, Giovanni
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3260 - 3268
