3,4,5,4'-四甲氧基二苯乙烯合成路线 （共 35 条）
反应条件
1: 4-methoxybenzyl-triphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1.5 h; 2: 3,4,5-trimethoxy-benzaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; Wittig reaction; 19 h;
参考文献
Chang, Jang-Yang; Yang, Ming-Fang; Chang, Chi-Yen; Chen, Chi-Ming; Kuo, Ching-Chuan; Liou, Jing-Ping
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6412 - 6415
反应条件
1: (4-(methoxy)benzyl)triethylphosphonium bromide in water T=20°C; 0.25 h; 2: With sodium hydroxide in water 0.0333333 h; 3: 3,4,5-trimethoxy-benzaldehyde in water T=70°C; Wittig reaction; 3 h; optical yield given as percent de;
参考文献
McNulty, James; Das, Priyabrata
European Journal of Organic Chemistry, 2009 , # 24 p. 4031 - 4035
反应条件
1: 1-bromomethyl-4-methoxy-benzene With diethylphosphinoethane T=0 - 20°C; 0.5 h; Inert atmosphere; 2: With lithium hydroxide hydrate in water T=20°C; 0.0333333 h; 3: 3,4,5-trimethoxy-benzaldehyde in water T=70°C; Wittig reaction; 3 h;
参考文献
McNulty, James; Das, Priyabrata
European Journal of Organic Chemistry, 2009 , # 24 p. 4031 - 4035
反应条件
1: (4-methoxybenzyl)triphenylphosphonium chloride With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: 3,4,5-trimethoxy-benzyl alcohol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 12 h; Inert atmosphereReflux;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
1,2-dibromo-1,1,2,2-tetrafluoroethane in tert-butyl alcohol Ramberg-Baecklund reaction; 12 h; Heating;
参考文献
Robinson, James E.; Taylor, Richard J. K.
Chemical Communications, 2007 , # 16 p. 1617 - 1619
反应条件
[Pd2(dibenzylideneacetone)3]*dibenzylideneacetone; sodium acetate in benzonitrile T=25°C; Heck arylation reaction; 0.3 h;
参考文献
Moro, Angelica Venturini; Cardoso, Flavio Sega P.; Correia, Carlos Roque D.
Tetrahedron Letters, 2008 , vol. 49, # 39 p. 5668 - 5671
反应条件
15-crown-5; sodium hydride in tetrahydrofuran
参考文献
Azzena, Ugo; Dettori, Giovanna; Idini, Maria Vittoria; Pisano, Luisa; Sechi, Grazia
Tetrahedron, 2003 , vol. 59, # 40 p. 7961 - 7966
反应条件
C27H21F3N6OPd; tetrabutylammomium bromide; sodium acetate T=140°C; Heck reaction; 12 h; Inert atmosphere;
参考文献
Sie, Ming-Han; Hsieh, Yuan-Hsin; Tsai, Yi-Hua; Wu, Jia-Rong; Chen, Shih-Jung; Kumar, P. Vijaya; Lii, Jenn-Huei; Lee, Hon Man
Organometallics, 2010 , vol. 29, # 23 p. 6473 - 6481
反应条件
sodium hydride in benzene 16 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2579 - 2588
反应条件
nickel in tetrahydrofuran Wittig type olefination; 12 h; Reflux;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
Tetrahedron Letters, 2009 , vol. 50, # 25 p. 3070 - 3073
