3,4,5,4'-四甲氧基二苯乙烯合成路线 （共 35 条）
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=80°C; 1 h;
参考文献
Organic Preparations and Procedures International, , vol. 45, # 4 p. 304 - 313
反应条件
1: 5-(chloromethyl)-1,2,3-trimethoxybenzene With tributylphosphine in tetrahydrofuran T=0°C; Wittig reaction; 0.0833333 h; 2: 4-methoxy-benzaldehyde With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; Wittig reaction; 16 h; optical yield given as percent dediastereoselective reaction;
参考文献
Synthetic Communications, , vol. 39, # 12 p. 2178 - 2195
反应条件
1: PBr3 / CH2Cl2 / 0.75 h / -5 °C 2: 73 percent / 2.17 h / 140 - 180 °C 3: 76 percent / NaH; 15-crown-5 / tetrahydrofuran View Scheme
参考文献
Tetrahedron, , vol. 59, # 40 p. 7961 - 7966
反应条件
1: 73 percent / 2.17 h / 140 - 180 °C 2: 76 percent / NaH; 15-crown-5 / tetrahydrofuran View Scheme
参考文献
Tetrahedron, , vol. 59, # 40 p. 7961 - 7966
反应条件
1: 64 percent / decalin / 3 h / Heating 2: 78 percent / Bu3SnH, AIBN / benzene / 2 h / Heating 3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min; 2.) THF, r.t., 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 36 p. 6733 - 6736
反应条件
1: 78 percent / Bu3SnH, AIBN / benzene / 2 h / Heating 2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min; 2.) THF, r.t., 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 36 p. 6733 - 6736
反应条件
1: 98 percent / LDA 2: 93 percent / NaBH4 3: 60 percent / HCl / benzene / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 145 - 148
反应条件
1: 93 percent / NaBH4 2: 60 percent / HCl / benzene / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 145 - 148
反应条件
1: 95 percent / phosphorus tribromide / CH2Cl2 / 12 h / 0 °C 2: toluene / 6 h / Heating 3: 0.4 g / n-butyllithium / hexane; tetrahydrofuran / 16 h / -78 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 42, # 6 p. 841 - 850
反应条件
nickel in tetrahydrofuran Wittig type olefination; 12 h; Reflux; optical yield given as percent de;
参考文献
Tetrahedron Letters, , vol. 50, # 25 p. 3070 - 3073
