1-[(2R,4S,5R)-4-羟基-5-(羟基甲基)四氢噻吩-2-基]-5-甲基嘧啶-2,4-二酮合成路线 （共 12 条）
反应条件
1: 1.) mercuric bromide, cadmium carbonate, 2.) methanol / 1.) toluene, reflux, 24 h, 2.) H2O, 30 min
2: 1.) 2 M BCl3, 2.) CH3OH / 1.) CH2Cl2, -78 deg C, 5 h, 2.) CH2Cl2, from -78 deg C to RT, 1 h
View Scheme
参考文献
Dyson; Coe; Walker
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2782 - 2786
反应条件
1: 85 percent / pyridine / 0.5 h / 100 °C
2: 75 percent / (diethylamido)sulfur trifluoride / CH2Cl2 / 0.25 h / -78 °C
3: 65 percent / NaN3 / dimethylformamide; H2O / 48 h / Heating
4: 55 percent / 80percent aq. AcOH / 2 h / Heating
View Scheme
参考文献
Dyson; Coe; Walker
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2782 - 2786
