3-甲氧基氨基巴豆酸甲酯合成路线 （共 10 条）
反应条件
silica gel in water T=20°C; 15 h;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6023 - 6026
反应条件
1: 59 percent / 3 h / Ambient temperature 2: piperidine / toluene / 96 h / Heating View Scheme
参考文献
Bulletin des Societes Chimiques Belges, , vol. 105, # 5 p. 259 - 272
反应条件
18 h; Ambient temperature;
参考文献
Synthesis, , # 7 p. 1112 - 1116
反应条件
1.) RT, 2 months, 2.) toluene, reflux, 20 h; Multistep reaction;
参考文献
Bulletin des Societes Chimiques Belges, , vol. 105, # 4 p. 189 - 204
反应条件
in methanol T=25 - 30°C;
参考文献
Mukherjee, Anita; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, p. 537 - 541
反应条件
in methanol T=25 - 30°C;
参考文献
Mukherjee, Anita; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, p. 537 - 541
反应条件
1.1: nitromethane / 24 h / 20 °C
2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h
2.2: 3 h / 20 °C
3.1: acetic acid; nitric acid / 2 h / -10 - 20 °C
4.1: tin; hydrogenchloride / water; ethanol / 0.5 h / |Reflux
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
View Scheme
参考文献
Schaefer, Anja; Burstein, Ethan S.; Olsson, Roger
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1944 - 1947
反应条件
copper diacetate in N,N-dimethyl acetamide
T=110°C; 24 h; Sealed tube;
参考文献
WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER; Neumann, Julia; Suri, Mamta; Glorius, Frank
Patent: US2013/12715 A1, 2013 ;
Location in patent: Paragraph 0170 ;
反应条件
1.1: nitromethane / 24 h / 20 °C
2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h
2.2: 3 h / 20 °C
View Scheme
参考文献
Schaefer, Anja; Burstein, Ethan S.; Olsson, Roger
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1944 - 1947
