5-溴甲基噻吩-2-甲腈合成路线 （共 10 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 5 h; Heating;
参考文献
Ho, Jonathan Z.; Gibson, Tony S.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 743 - 748
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Corvas International, Inc.
Patent: US2002/37857 A1, 2002 ;
Title/Abstract Full Text Show Details
Corvas International, Inc.
Patent: US6586405 B2, 2003 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
LG Life Sciences, Ltd.
Patent: US6492402 B1, 2002 ;
US 6492402 B1
反应条件
triphenylphosphine in tetrahydrofuran; chloroform; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US5710130 A1, 1998 ;
US 5710130 A
反应条件
1: dimethylformamide / Heating 2: 86 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 6 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 17 p. 3612 - 3622
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran Bromination; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 18 p. 3557 - 3571
反应条件
1: NaBH4 / methanol / 20 °C 2: dimethylformamide / Heating 3: CBr4; PPh3 / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1017 - 1022
反应条件
1: dimethylformamide / Heating 2: CBr4; PPh3 / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1017 - 1022
反应条件
1: 84 percent / NBS; HClO4 / CCl4 2: 87 percent / dimethylformamide / 4 h / Heating 3: 91 percent / NBS; AIBN / CCl4 / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 743 - 748
反应条件
N-bromosuccinmide; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; dibenzoyl peroxide in tetrachloromethane; chloroform; water; acetic acid
参考文献
Schering Aktiengesellschaft
Patent: US5135937 A1, 1992 ;
