4,5,6,7-四氢-4-苯并噻吩合成路线 （共 38 条）
反应条件
1: NaBH4 / methanol / 0.5 h / 0 °C 2: 40 percent / p-toluenesulfonic acid / toluene / 24 h / Heating View Scheme
参考文献
Labadie, Sharada S.
Synthetic Communications, 1998 , vol. 28, # 13 p. 2531 - 2539
反应条件
1: 99 percent / NH2OH*HCl; aq. NaOAc / ethanol 2: 92 percent / pyridine 3: 60 percent / aq. KOAc / ethanol View Scheme
参考文献
Cho, Hidetsura; Murakami, Kengo; Nakanishi, Hiroyuki; Isoshima, Hirotaka; Hayakawa, Kazuhide; Uchida, Itsuo
Heterocycles, 1998 , vol. 48, # 5 p. 919 - 927
反应条件
ammonium acetate; sodium cyanoborohydride in methanol 168 h; Ambient temperature;
参考文献
Cauquil-Caubere, Isoline; Kamenka, Jean-Marc
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 867 - 877
反应条件
T=185°C; Erhitzen des Reaktionsprodukts mit wss. Salzsaeure;
参考文献
Kloetzel et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 1511,1514
反应条件
1: hydrazine hydrate; potassium hydroxide; diethylene glycol / 215 °C 2: aluminium chloride 3: alkaline aqueous potassium hypobromite solution; dioxane View Scheme
参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1953 , p. 62,68, 713, 717
反应条件
1: 99 percent / NH2OH*HCl; aq. NaOAc / ethanol 2: 92 percent / pyridine 3: 60 percent / aq. KOAc / ethanol 4: 91 percent / BH3*S(CH3)2 / tetrahydrofuran View Scheme
参考文献
Cho, Hidetsura; Murakami, Kengo; Nakanishi, Hiroyuki; Isoshima, Hirotaka; Hayakawa, Kazuhide; Uchida, Itsuo
Heterocycles, 1998 , vol. 48, # 5 p. 919 - 927
反应条件
amalgamated zinc; iodine; benzene Reagens 4: Aether; Erhitzen des nach der Hydrolyse und Destillation erhaltenen Ester-Gemisches mit Tetrachlor-<1,4>benzochinon in Xylol und Erhitzen des Reaktionsprodukts mit wss. Natronlauge;
参考文献
Kloetzel et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 1511,1514
反应条件
bromine; acetic acid in water T=0 - 20°C; 18.33 h;
参考文献
ARES TRADING S.A.; QUATTROPANI, Anna; SWINNEN, Dominique
Patent: WO2013/178322 A1, 2013 ;
Location in patent: Page/Page column 64; 65 ;
反应条件
bromine in tetrachloromethane T=-10 - 20°C; 2.08333 h;
参考文献
Dahnke, Karl Robert; Lin, Ho-Shen; Richett, Michael Enrico; Shih, Chuan; Wang, Q May; Zhang, Bo
Patent: US2008/306082 A1, 2008 ;
Location in patent: Page/Page column 25 ;
反应条件
copper(ll) bromide in chloroform; ethyl acetate 8 h; Heating;
参考文献
Chenard, Bertrand L.; McConnell, J. Russell; Swenton, John S.
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4312 - 4317
