1-[3-[[叔丁基二甲基硅烷基]氧基]苯基]-1-丙酮合成路线 （共 9 条）
反应条件
pyridinium chlorochromate in dichloromethane T=20°C;
参考文献
Baylor University
Patent: US2009/76076 A1, 2009 ;
Location in patent: Page/Page column 18 ;
US 20090076076 A1
反应条件
1H-imidazole in N,N-dimethyl-formamide 18 h; Ambient temperature;
参考文献
Bird; Bruneau; Crawley; Edwards; Foster; Girodeau; Kingston; McMillan
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2176 - 2186
反应条件
in N-methyl-acetamide
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC; ICI PHARMA
Patent: EP381375 A1, 1990 ;
反应条件
in N-methyl-acetamide
参考文献
ICI Pharma; Imperial Chemical Industries PLC
Patent: US5089513 A1, 1992 ;
US 5089513 A
反应条件
1: 91 percent / Mg / diethyl ether / 20 °C 2: 86 percent / PCC / CH2Cl2 / 20 °C View Scheme
参考文献
Siles, Rogelio; Chen, Shen-En; Zhou, Ming; Pinney, Kevin G.; Trawick, Mary Lynn
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4405 - 4409
反应条件
1: 92 percent / NEt3; DMAP / 2.5 h / 20 °C 2: 91 percent / Mg / diethyl ether / 20 °C 3: 86 percent / PCC / CH2Cl2 / 20 °C View Scheme
参考文献
Siles, Rogelio; Chen, Shen-En; Zhou, Ming; Pinney, Kevin G.; Trawick, Mary Lynn
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4405 - 4409
反应条件
1: 92 percent / NEt3; DMAP / 2.5 h / 20 °C 2: 91 percent / Mg / diethyl ether / 20 °C 3: 86 percent / PCC / CH2Cl2 / 20 °C View Scheme
参考文献
Siles, Rogelio; Chen, Shen-En; Zhou, Ming; Pinney, Kevin G.; Trawick, Mary Lynn
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4405 - 4409
反应条件
1: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 2.) ether, hexane, from -70 deg C to RT 2: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 3: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 4: 80 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature View Scheme
参考文献
Bird; Bruneau; Crawley; Edwards; Foster; Girodeau; Kingston; McMillan
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2176 - 2186
反应条件
1: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 2.) ether, hexane, from -70 deg C to RT 2: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 3: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Bird; Bruneau; Crawley; Edwards; Foster; Girodeau; Kingston; McMillan
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2176 - 2186
