1: 91 percent / diethyl ether / 1 h / Ambient temperature 2: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 3: 76 percent / H2 / 30percent Pd/C / ethyl acetate 4: 80 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature View Scheme

1: 91 percent / diethyl ether / 1 h / Ambient temperature 2: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 3: 76 percent / H2 / 30percent Pd/C / ethyl acetate View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1361988', constants.ctx, '0')">oxalyl dichloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506008', constants.ctx, '0')">dimethyl sulfoxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=-55 - -50&deg;C;&nbsp;0.25&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h<br />2: 100 percent / DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -55 - -50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 93 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature<br />2: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h<br />3: 100 percent / DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -55 - -50 &deg;C<br /> <br /> &nbsp;