5,6,7,8-四氢-2-甲基-吡啶并[4,3-d]嘧啶-4(3h)-酮合成路线 （共 5 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol 10 h; Heating;
参考文献
Huber, Imre; Fueloep, Ferenc; Lazar, Janos; Bernath, Gabor; Toth, Gabor
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 1 p. 157 - 162
反应条件
1: 60 percent / NaOEt / ethanol / 12 h / 100 °C 2: 83 percent / H2, aq. HCl / 10percent Pd-C / methanol / 10 h / Heating View Scheme
参考文献
Lazar; Bernath
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 1885 - 1892
反应条件
1: sodium methoxide / 3 h / 100 °C / in xylene or toluene 2: 92 percent / hydrogen / 10 percent Pd/C / aq. acetic acid 3: sodium ethoxide / ethanol / 12 h / 100 °C View Scheme
参考文献
Lazar; Bernath
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 1885 - 1892
反应条件
sodium ethanolate in ethanol T=100°C; 12 h; Yield given;
参考文献
Lazar; Bernath
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 1885 - 1892
反应条件
sodium in ethanol T=100°C;
参考文献
Lockman, Jeffrey W.; Murphy, Brett R.; Zigar, Daniel F.; Judd, Weston R.; Slattum, Paul M.; Gao, Zhong-Hua; Ostanin, Kirill; Green, Jeremy; McKinnon, Rena; Terry-Lorenzo, Ryan T.; Fleischer, Tracey C.; Boniface, J. Jay; Shenderovich, Mark; Willardsen, J. Adam
Journal of Medicinal Chemistry, 2010 , vol. 53, # 24 p. 8734 - 8746
