3,5-二异丙基-4-羟基苯甲酸合成路线 （共 6 条）
反应条件
1: With sulfuric acid in water T=15 - 65°C; Friedel Crafts Alkylation; 4 h; 2: in water
参考文献
WO2011/161687 A1, ;
Page/Page column 8 ;
反应条件
hydrogenchloride; sodium methylate in N,N-dimethyl acetamide; water
反应条件
sulfuric acid T=10 - 65°C; Friedel-Crafts Alkylation;
参考文献
WO2013/35103 A1, ;
Page/Page column 5 ;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 5019,5021
反应条件
1: With sodium hydroxide in ethylene glycol T=140 - 145°C; 7 h; Inert atmosphere; 2: With hydrogenchloride in water; ethylene glycol pH=1 - 2; 1 h;
参考文献
HARMAN FINOCHEM LIMITED; JAIN, Kirti Prakash; EDAKI, Dhananjay Uddhavrao; MINHAS, Harpreet Singh; MINHAS, Gurpreet Singh
Patent: WO2011/161687 A1, 2011 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: NaOMe
2: (i) SOCl2, (ii) NH3
View Scheme
参考文献
Moffett,R.B.; Seay,P.H.
J. Med. Pharm. Chem., 1960 , vol. 2, p. 201 - 212
