Dexelvucitabine合成路线 （共 13 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 1.5 h; Ambient temperature;
参考文献
Shi, Junxing; McAtee, J. Jeffrey; Wirtz, Susan Schlueter; Tharnish, Phillip; Juodawlkis, Amy; Liotta, Dennis C.; Schinazi, Raymond F.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 5 p. 859 - 867
反应条件
sodium methylate in methanol 19 h;
参考文献
Choudhury, Anusuya; Pierce, Michael E.; Nguyen, Dieu; Storace, Louis; Confalone, Pat N.
Tetrahedron Letters, 2005 , vol. 46, # 47 p. 8099 - 8102
反应条件
1: 95.4 percent / pyridine / 6.5 h / 60 - 65 °C 2: H2SO4 / acetic acid; H2O / 5 h / 95 °C 3: 23 percent / I2; polymer bound triphenylphosphine; imidazole / CH2Cl2 / 1 h / 20 °C 4: 35 percent / DBU / Pd(Ph3P)4 / acetonitrile; 1-methyl-pyrrolidin-2-one / 48 h / 33 °C 5: 82 percent / NaOMe / methanol / 19 h View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 47 p. 8099 - 8102
反应条件
N-butylamine in tetrahydrofuran
参考文献
Chen, Shu-Hui; Lin, Stanley; King, Ivan; Spinka, Tracy; Dutschman, Ginger E.; Gullen, Elizabeth A.; Cheng, Yung-Chi; Doyle, Terrence W.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3245 - 3250
反应条件
1: 35 percent / DBU / Pd(Ph3P)4 / acetonitrile; 1-methyl-pyrrolidin-2-one / 48 h / 33 °C 2: 82 percent / NaOMe / methanol / 19 h View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 47 p. 8099 - 8102
反应条件
1: H2SO4 / acetic acid; H2O / 5 h / 95 °C 2: 23 percent / I2; polymer bound triphenylphosphine; imidazole / CH2Cl2 / 1 h / 20 °C 3: 35 percent / DBU / Pd(Ph3P)4 / acetonitrile; 1-methyl-pyrrolidin-2-one / 48 h / 33 °C 4: 82 percent / NaOMe / methanol / 19 h View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 47 p. 8099 - 8102
反应条件
1: 86 percent / 30 percent H2O2, pyridine / CH2Cl2 / 0.83 h / 0 - 20 °C 2: 93 percent / TBAF / tetrahydrofuran / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 5 p. 859 - 867
反应条件
1: 4 M H2SO4, 85percent AcOH / tetrahydrofuran / 60 °C 2: I2, Ph3P, imidazole / CH2Cl2 / Ambient temperature 3: NIS / 1,2-dichloro-ethane / Ambient temperature 4: 51 percent / Zn, AcOH / ethanol; ethyl acetate / 70 °C 5: 50 percent / n-BuNH2 / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 22 p. 3245 - 3250
反应条件
1: 95 percent / conc. H2SO4, acetone / Ambient temperature 2: pyridine / CH2Cl2 / 0 °C 3: 4 M H2SO4, 85percent AcOH / tetrahydrofuran / 60 °C 4: I2, Ph3P, imidazole / CH2Cl2 / Ambient temperature 5: NIS / 1,2-dichloro-ethane / Ambient temperature 6: 51 percent / Zn, AcOH / ethanol; ethyl acetate / 70 °C 7: 50 percent / n-BuNH2 / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 22 p. 3245 - 3250
反应条件
1: NIS / 1,2-dichloro-ethane / Ambient temperature 2: 51 percent / Zn, AcOH / ethanol; ethyl acetate / 70 °C 3: 50 percent / n-BuNH2 / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 22 p. 3245 - 3250
