1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; formic acid; triethylamine in N,N-dimethyl-formamide T=60°C; 12 h;

1: Et3N, 1,1'-bis(diphenylphosphino)ferrocene, Pd(OAc)2 / dimethylsulfoxide / 48 h / 70 °C 2: aq. NaOH / methanol / Ambient temperature 3: SOCl2 / 3 h / 60 °C 4: aq. conc. NH3 / 2 h / Ambient temperature 5: POCl3 / dimethylformamide / 1 h / 60 °C View Scheme