四氢-2H-吡喃-4-甲烷硫酸盐合成路线 （共 9 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 2.5 h;
参考文献
Incyte Corporation; Lu, Liang; He, Chunhong; Yao, Wenqing
Patent: US2014/45814 A1, 2014 ;
Location in patent: Paragraph 0245; 0246 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 30 °C / Inert atmosphere 2: triethylamine / toluene / 20 °C View Scheme
参考文献
Gruenenthal GmbH
Patent: US2012/46301 A1, 2012 ;
US 20120046301 A1
反应条件
1: Raney nickel / Hydrogenation 2: pyridine View Scheme
参考文献
Heuberger; Owen
Journal of the Chemical Society, 1952 , p. 910,913
反应条件
1: 4-bromo(1H)-pyrazole With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 1 h; 2: tetrahydro-2H-pyran-4-yl methanesulfonate in N,N-dimethyl-formamide; mineral oil T=0 - 100°C;
参考文献
Zhang, Dengyou; Zhang, Xiaowei; Ai, Jing; Zhai, Yun; Liang, Zhongjie; Wang, Ying; Chen, Yi; Li, Chunpu; Zhao, Fei; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6804 - 6820
参考文献
Boehringer Ingelheim International GmbH
Patent: US2010/76029 A1, 2010 ;
Location in patent: Page/Page column 39 ;
US 20100076029 A1
反应条件
in acetonitrile T=90°C; 2 h;
参考文献
Incyte Corporation; Lu, Liang; He, Chunhong; Yao, Wenqing
Patent: US2014/45814 A1, 2014 ;
Location in patent: Paragraph 0247; 0248 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 80 °C 2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 80 °C / Inert atmosphere View Scheme
参考文献
Zhang, Dengyou; Zhang, Xiaowei; Ai, Jing; Zhai, Yun; Liang, Zhongjie; Wang, Ying; Chen, Yi; Li, Chunpu; Zhao, Fei; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6804 - 6820
反应条件
hydrazine in ethanol T=70 - 80°C; 3 - 8 h; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1661894 A1, 2006 ;
Location in patent: Page/Page column 7; 12 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene T=20 - 130°C;
参考文献
Suto; Stier; Werbel; Arundel-Suto; Leopold; Elliott; Sebolt-Leopold
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2484 - 2488
