(R)-N-Boc-2-哌啶甲醇合成路线 （共 14 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 4.25 h; 2: With water in tetrahydrofuran 0.166667 h;
参考文献
DECODE CHEMISTRY, INC.
Patent: US2007/66820 A1, 2007 ;
Location in patent: Page/Page column 41 ;
US 20070066820 A1
反应条件
1: BH3 / tetrahydrofuran / Ambient temperature 2: Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 4 p. 700 - 709
反应条件
1: With potassium hydroxide in methanol 2: With hydrogenchloride in methanol; chloroform; water
参考文献
LEAD DISCOVERY CENTER GMBH; BAYER INTELLECTUAL PROPERTY GMBH; RUeHTER, Gerd; KOCH, Uwe; NUSSBAUMER, Peter; SCHULTZ-FADEMRECHT, Carsten; EICKHOFF, Jan
Patent: WO2012/117048 A1, 2012 ;
Location in patent: Page/Page column 53 ;
WO 2012/117048 A1
反应条件
1: 6-((S)-4-Isopropyl-2-oxo-oxazolidin-3-yl)-pyridine-2-carbaldehyde With hydrogen; acetic acid; 20 palladium hydroxide on carbon T=20°C; P=75007.5 Torr; 20 h; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=0 - 20°C; 3 h; Product distribution / selectivity;
参考文献
STUDIENGESELLSCHAFT KOHLE MBH
Patent: WO2005/49570 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 96 percent / N,N-diisopropylethylamine / dioxane; H2O / 48 h / Ambient temperature 2: 86 percent / BH3*Me2S / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 9 p. 1550 - 1557
参考文献
Journal of the American Chemical Society, , vol. 117, # 36 p. 9369 - 9370
反应条件
1: (S)-1-(2,2,2-Trifluoro-acetyl)-piperidine-2-carboxylic acid (S)-3,4,4-trimethyl-2-oxo-tetrahydro-furan-3-yl ester With sodium tetrahydroborate in ethanol 1.5 h; 2: di-tert-butyl dicarbonate With sodium hydroxide in 1,4-dioxane; water T=20°C; 12 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1685 - 1689
反应条件
sodium tetrahydroborate in ethanol T=20°C; 1 h;
参考文献
Chemistry - A European Journal, , vol. 19, # 51 p. 17584 - 17588
反应条件
1.1: 72 percent / Et3N / methanol 2.1: 60 percent / 4-dimethylaminopyridine; dicyclohexylcarbodiimide / toluene / 15 h / 20 °C 3.1: NaBH4 / ethanol / 1.5 h 3.2: NaOH / dioxane; H2O / 12 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1685 - 1689
反应条件
1.1: 60 percent / 4-dimethylaminopyridine; dicyclohexylcarbodiimide / toluene / 15 h / 20 °C 2.1: NaBH4 / ethanol / 1.5 h 2.2: NaOH / dioxane; H2O / 12 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1685 - 1689
