(S)-N-Boc-2-哌啶甲醇合成路线 （共 23 条）
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Bhat, Chinmay; Tilve, Santosh G.
Tetrahedron, 2013 , vol. 69, # 30 p. 6129 - 6143
反应条件
boron trifluoride diethyl etherate
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=25°C; P=1034.32 Torr; 8 h;
参考文献
Shaikh, Tanveer Mahamadali; Sudalai, Arumugam
Tetrahedron Asymmetry, 2009 , vol. 20, # 19 p. 2287 - 2292
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C; 8 h;
参考文献
Shaikh, Tanveer Mahamadali; Sudalai, Arumugam
European Journal of Organic Chemistry, 2010 , # 18 p. 3437 - 3444
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 6.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 6.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 89 percent / NaH / tetrahydrofuran / 6 h / 20 °C 2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 5 h / -78 °C 2.2: 80 percent / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C 3.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 4.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 1.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 2.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 3.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 86 percent / p-TsOH / toluene / 0.33 h 2.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 2.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 3.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 4.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 2.1: 86 percent / p-TsOH / toluene / 0.33 h 3.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 3.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 4.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 5.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
