(S)-N-Boc-2-哌啶甲醇合成路线 （共 23 条）
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 5 h / -78 °C 1.2: 80 percent / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C 2.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 3.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 2: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1: N,N-diisopropylethylamine / dioxane; H2O / 48 h / Ambient temperature 2: BH3*Me2S / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 9 p. 1550 - 1557
反应条件
1: (S)-1-(2,2,2-Trifluoro-acetyl)-piperidine-2-carboxylic acid (S)-3,4,4-trimethyl-2-oxo-tetrahydro-furan-3-yl ester With sodium tetrahydroborate in ethanol 1.5 h; 2: di-tert-butyl dicarbonate With sodium hydroxide in 1,4-dioxane; water T=20°C; 12 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1685 - 1689
反应条件
sodium tetrahydroborate in ethanol T=20°C; 1 h;
参考文献
Chemistry - A European Journal, , vol. 19, # 51 p. 17584 - 17588
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 15 min, 2) THF, -78 to -10 deg C 2: 90 percent / t-BuOK / dimethylformamide / 2 h / Ambient temperature 3: 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 4: PPTS, EtOH / 6 h / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 2 p. 237 - 240
反应条件
1.1: 72 percent / Et3N / methanol 2.1: 60 percent / 4-dimethylaminopyridine; dicyclohexylcarbodiimide / toluene / 15 h / 20 °C 3.1: NaBH4 / ethanol / 1.5 h 3.2: NaOH / dioxane; H2O / 12 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1685 - 1689
反应条件
1.1: 60 percent / 4-dimethylaminopyridine; dicyclohexylcarbodiimide / toluene / 15 h / 20 °C 2.1: NaBH4 / ethanol / 1.5 h 2.2: NaOH / dioxane; H2O / 12 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1685 - 1689
反应条件
1: 95 percent / 1 M aq.K2CO3 / tetrahydrofuran / Ambient temperature 2: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 11 p. 1951 - 1965
反应条件
kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 11 p. 1951 - 1965
