1-N-boc-4-疏基哌啶合成路线 (共 7 条)
反应条件
methanol; sodium methylate T=0 - 20°C; 5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/30366 A1, 2007 ;
Location in patent: Page/Page column 136 ;
反应条件
1: With hydrogen sulfide in isopropyl alcohol T=20°C; 18 h; 2: With sodium tetrahydroborate in isopropyl alcohol T=80°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; DEMEESE, Jason; GAUDINO, John; NEITZEL, Alicia, Tarin; LUNGHOFER, Paul; JEONGBEOB, Seo; HONGQI, Tian; YOUNG, Wendy, B.; SUTHERLIN, Daniel, P.
Patent: WO2009/33084 A1, 2009 ;
Location in patent: Page/Page column 100 ;
WO 2009/033084 A1
反应条件
sodium tetrahydroborate; ethanol T=0 - 80°C; 2.33333 h; Inert atmosphere;
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; GOSSELIN, Francis; YUEN, Po-Wai; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/127267 A1, 2013 ;
Location in patent: Page/Page column 102; 103 ;
反应条件
acetic acid in methanol
参考文献
Sankyo Company, Limited
Patent: US5977152 A1, 1999 ;
反应条件
methanol; sodium methylate T=0 - 20°C; 5 h;
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
Location in patent: Page/Page column 41; 42 ;
反应条件
1: triethylamine / dichloromethane / 12 h / 0 - 20 °C 2: triethylamine / N,N-dimethyl-formamide / 100 °C 3: methanol; sodium methylate / 5 h / 0 - 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
反应条件
1: triethylamine / N,N-dimethyl-formamide / 100 °C 2: methanol; sodium methylate / 5 h / 0 - 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;