1H-苯并咪唑-2-硫醇合成路线 （共 177 条）
反应条件
1: 70 percent / Br2, 48percent aq. HBr, acetic acid / 4 h / Ambient temperature
2: 75 percent / 1 N aq. NaOH / 2 h / 40 °C
View Scheme
参考文献
David, Wendi M.; Kumar, Dalip; Kerwin, Sean M.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 22 p. 2509 - 2512
反应条件
sodium hydride in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Miyashita, Akira; Nagasaki, Izuru; Kawano, Akiko; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1997 , vol. 45, # 4 p. 745 - 755
反应条件
sodium ethanolate in ethanol
20 h; Heating;
参考文献
Ram; Wise; Townsend
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1269 - 1274
反应条件
potassium carbonate in tetrahydrofuran
88 h; Ambient temperature;
参考文献
Ram; Wise; Townsend
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1269 - 1274
反应条件
1: 1.) NaH / 1.) DMF, a) 0 deg C, 20 min, b) RT, 30 min, 2.) DMF, RT, 1 h
2: aq. KMnO4, AcOH / 2 h / 25 °C
View Scheme
参考文献
Orjales; Bordell; Rubio
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 707 - 718
反应条件
1: 92 percent / NaOH, Na2CO3 / ethanol; H2O / 1.5 h / Heating
2: 86 percent / mCPBA / CH2Cl2 / 1.) -10 deg C 15 min, 2.) RT 1 h
View Scheme
参考文献
Graber, David R.; Morge, Raymond A.; Sih, John C.
Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4620 - 4622
反应条件
1: acetic acid
2: aq. HCl / dioxane / Heating
View Scheme
参考文献
Bell; Wei
Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 524 - 530
反应条件
dihydrogen peroxide; zirconium tetrachloride in water; acetonitrile
T=25°C; 0.0333333 h;
参考文献
Bahrami, Kiumars; Khodaei, Mohammad Mehdi; Soheilizad, Mehdi
Synlett, 2009 , # 17 p. 2773 - 2776
反应条件
reconstructed hydrotalcite in ethanol
T=70°C; 0.333333 h; Microwave irradiationCooling; Reagent/catalystTime;
参考文献
Cruz-Gonzalez, Deysi Y.; Gonzalez-Olvera, Rodrigo; Angeles-Beltran, Deyanira; Negron-Silva, Guillermo E.; Santillan, Rosa
Synthesis (Germany), 2013 , vol. 45, # 23 p. 3281 - 3287
反应条件
reconstructed hydrotalcite in ethanol
T=70°C; 3.5 h; Microwave irradiationCooling; Reagent/catalyst;
参考文献
Cruz-Gonzalez, Deysi Y.; Gonzalez-Olvera, Rodrigo; Angeles-Beltran, Deyanira; Negron-Silva, Guillermo E.; Santillan, Rosa
Synthesis (Germany), 2013 , vol. 45, # 23 p. 3281 - 3287
