1H-苯并咪唑-2-硫醇合成路线 （共 177 条）
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 6 p. 1215 - 1220
反应条件
1: 2-acetoxymethyl-4-methoxy-3-methylpyridine With thionyl chloride in chloroform 1 h; Reflux; 2: 2-mercaptobenzoimidazole With sodium methylate in methanol 1 h; Reflux;
参考文献
Arigen, Pharmaceuticals, Inc.
Patent: EP2103608 A1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
sodium hydroxide in water T=25°C; 3 h;
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
sodium hydroxide in ethanol Heating; Yield given;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: 55 percent / ethanol / 2 h 2: 39 percent / 85percent m-CPBA / CHCl3 / 0.5 h / -10 °C View Scheme
参考文献
Adelstein, Gilbert W.; Yen, Chung H.; Haack, Richard A.; Yu, Stella; Gullikson, Gary; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1215 - 1220
反应条件
thionyl chloride; sodium methylate 1) CHCl3, reflux, 2) MeOH, reflux; Yield given. Multistep reaction;
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
反应条件
sodium ethanolate 1.) EtOH, 30 min, 2.) EtOH, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Koos, M.
Monatshefte fuer Chemie, 1994 , vol. 125, # 8/9 p. 1011 - 1016
反应条件
Multistep reaction. Further byproducts given;
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
sodium hydroxide in water T=25°C; 4 h;
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
sodium hydroxide in methanol; water T=10 - 35°C; 4 h;
参考文献
WO2004/56803 A1, ;
Page 7,8 ;
