1H-苯并咪唑-2-硫醇合成路线 （共 177 条）
反应条件
hydrogenchloride; sodium hydroxide; thionyl chloride in methanol; water
反应条件
sodium hydroxide in water Flow reactor;
参考文献
Organic Process Research and Development, , vol. 17, # 10 p. 1272 - 1276
反应条件
thionyl chloride; sodium methylate 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858
反应条件
1: With sodium hydroxide in water T=20 - 30°C; 2 h; 2: With sodium hydroxide; sodium hypochlorite in pyridine; water T=5 - 10°C; 4 - 6 h;
参考文献
WO2006/117802 A2, ;
Page/Page column 8-9 ;
反应条件
sodium hydroxide in ethanol T=50°C; 2 h; Product distribution / selectivity;
参考文献
EP1775292 A1, ;
Page/Page column 13; 14 ;
反应条件
sodium hydroxide in water; acetone T=15 - 20°C; 0.75 h;
参考文献
Synthetic Communications, , vol. 39, # 2 p. 278 - 290
反应条件
1: 52 percent / triethylamine / acetonitrile / 20 °C 2: 29.5 percent / potassium hydroxide / dimethylsulfoxide / 336 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453
反应条件
1: 52 percent / triethylamine / acetonitrile / 20 °C 2: 29.5 percent / potassium hydroxide / dimethylsulfoxide / 336 h / 20 °C 3: 33.5 percent / aq. sodium carbonate; peracetic acid / CH2Cl2 / 20 h / 20 °C View Scheme
参考文献
Radl, Stanislav; Klecan, Ondrej; Havlicek, Jaroslav
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1447 - 1453
反应条件
1: NaOH / ethanol / Heating 2: Ac2O; pyridine / 0.17 h / Heating View Scheme
参考文献
Mavrova, Anelia Ts.; Anichina, Kamelya K.; Vuchev, Dimitar I.; Tsenov, Jordan A.; Kondeva, Magdalena S.; Micheva, Mitka K.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 19 p. 5550 - 5559
反应条件
1: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride; 2-mercaptobenzoimidazole With sodium hydroxide in water T=25 - 35°C; Inert atmosphere; 2: 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]thio]-1H-benzimidazole With water; (+)-Weinsaeure-diethylester in dichloromethane T=55 - 60°C; 0.25 h; Inert atmosphere;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; VENKATESH, Mummadi
Patent: WO2010/95144 A2, 2010 ;
Location in patent: Page/Page column 27 ;
