2,4-二氯-6-氟喹唑啉合成路线 （共 5 条）
反应条件
N,N-diethylaniline; trichlorophosphate 3 h; Reflux;
参考文献
Smits, Rogier A.; De Esch, Iwan J. P.; Zuiderveld, Obbe P.; Broeker, Joachim; Sansuk, Kamonchanok; Guaita, Elena; Coruzzi, Gabriella; Adami, Maristella; Haaksma, Eric; Leurs, Rob
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7855 - 7865
反应条件
1: bis(trichloromethyl) carbonate With triethylamine; triphenyl-phosphine oxide in chlorobenzene T=20°C; 0.5 h; Cooling with ice; 2: 2-amino-5-fluorobenzonitrile in chlorobenzene T=120°C; 10 h;
参考文献
Li, Zhenhua; Wu, Danli; Zhong, Weihui
Heterocycles, 2012 , vol. 85, # 6 p. 1417 - 1426
反应条件
1: phenol / 150 °C 2: trichlorophosphate View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1593 - 1597
反应条件
1: 200 °C 2: 70 percent / POCl3; N,N-dimethylaniline / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300
反应条件
sodium hydroxide in tetrahydrofuran T=20°C; 4 h;
参考文献
Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300
