1: With hydrogenchloride; water in methanol T=25 - 30°C; 3.16667 h; 2: With sodium hydroxide in methanol; water T=25 - 38°C; 3: With anhydrous calcium acetate in water T=48 - 58°C; 2 h;
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; De Lange, Ben; Elsenberg, Henricus Leonardus Marie; Vaessen, Henricus Wilhelmus Leonardus Marie
Patent: US2013/178636 A1, 2013 ;
Location in patent: Paragraph 0018 ;
1: With hydrogenchloride; methanol; water T=35°C; 3 h; 2: With calcium hydroxide powder in methanol; water; toluene T=70°C; 2 h; 3: in methanol; water T=20 - 78°C; 24.25 h;
1: With hydrogenchloride in methanol; water T=25°C; 3 h; 2: With sodium hydroxide in methanol; water T=25 - 38°C; 3: With anhydrous calcium acetate in water T=58°C; 1 h; Product distribution / selectivity;
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; LANGE, DE, Ben; ELSENBERG, Henricus, Leonardus, Marie
Patent: WO2012/32035 A1, 2012 ;
Location in patent: Page/Page column 9-10 ;
