(R)-2-甲酰基-1-哌啶甲酸叔丁酯合成路线 （共 14 条）
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; 0.5 h; 2: With potassium hydrogensulfate in diethyl ether; water T=0°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; SUN, Chongqing; EWING, William R.; BOLTON, Scott A.; GU, Zhengxiang; HUANG, Yanting; MURUGESAN, Natesan; ZHU, Yeheng
Patent: WO2012/125622 A1, 2012 ;
Location in patent: Page/Page column 123 ;
WO 2012/125622 A1
反应条件
1: With diisobutylaluminium hydride in toluene T=-78°C; 0.666667 h; 2: With methanol in toluene T=-78°C; 0.166667 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259862 A1, 2007 ;
Location in patent: Page/Page column 11 ;
US 20070259862 A1
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 3 h;
参考文献
Alibes, Ramon; Ballbe, Marta; Busque, Felix; De March, Pedro; Elias, Laia; Figueredo, Marta; Font, Josep
Organic Letters, 2004 , vol. 6, # 11 p. 1813 - 1816
反应条件
sodium periodate; sodium hydrogencarbonate in dichloromethane; water T=20°C; 1 h;
参考文献
Tetrahedron, , vol. 67, # 6 p. 1341 - 1347
反应条件
1: 96 percent / BH3*THF / 20 h / 20 °C 2: 76 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 6, # 11 p. 1813 - 1816
反应条件
1: BH3 / tetrahydrofuran / Ambient temperature 2: Ambient temperature 3: 1.) (COCl)2, DMSO, 2.) Et3N View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 4 p. 700 - 709
反应条件
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; hexane T=-78°C; 3 h; 2: With C12H26N2O in diethyl ether; hexane T=-78 - -40°C; 1.5 h; 3: N,N-dimethyl-formamide in diethyl ether; hexane T=-78 - 20°C; Resolution of racemate; optical yield given as percent ee;
参考文献
Chemical Communications, , # 35 p. 4174 - 4176
反应条件
1: Ambient temperature 2: 1.) (COCl)2, DMSO, 2.) Et3N View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 4 p. 700 - 709
反应条件
1: Ambient temperature 2: 1.) (COCl)2, DMSO, 2.) Et3N View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 4 p. 700 - 709
反应条件
1: RuCl2(tricyclohexylphosphine)2(benzylidene) / dichloromethane / 8 h / Reflux 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C 3: methanol; toluene-4-sulfonic acid / 5 h / 20 °C 4: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 1 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 67, # 6 p. 1341 - 1347
