Multi-step reaction with 4 steps 1.1: sodium iodide; 1,3,5-trishydroxybenzene; sodium nitrite / N,N-dimethyl-formamide / 5 - 30 °C / Inert atmosphere2.1: dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene; tetrahydrofuran / 4 h / 25 - 30 °C / Inert atmosphere3.1: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 0 - 10 °C4.1: hydrogenchloride; zinc / isopropyl alcohol; water / 2 h / 40 °C4.2: pH 12 - 13  

<b>Multi-step reaction with 4 steps<br /> </b>1.1: sodium iodide; 1,3,5-trishydroxybenzene; sodium nitrite / N,N-dimethyl-formamide / 5 - 30 &deg;C / Inert atmosphere<br />2.1: dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene; tetrahydrofuran / 4 h / 25 - 30 &deg;C / Inert atmosphere<br />3.1: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 0 - 10 &deg;C<br />4.1: hydrogenchloride; zinc / isopropyl alcohol; water / 2 h / 40 &deg;C<br />4.2: pH 12 - 13<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene; tetrahydrofuran / 4 h / 25 - 30 &deg;C / Inert atmosphere<br />2.1: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 0 - 10 &deg;C<br />3.1: hydrogenchloride; zinc / isopropyl alcohol; water / 2 h / 40 &deg;C<br />3.2: pH 12 - 13<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1.1: AlCl₃, aluminium chloride / dichloromethane / 4 h / 20 - 25 &deg;C / Industry scale<br />2.1: sodium iodide; 1,3,5-trishydroxybenzene; sodium nitrite / N,N-dimethyl-formamide / 5 - 30 &deg;C / Inert atmosphere<br />3.1: dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene; tetrahydrofuran / 4 h / 25 - 30 &deg;C / Inert atmosphere<br />4.1: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 0 - 10 &deg;C<br />5.1: hydrogenchloride; zinc / isopropyl alcohol; water / 2 h / 40 &deg;C<br />5.2: pH 12 - 13<br /> <br /> &nbsp;