1: trans-(1R,2S)-2-(3,4-difluorophenyl)-1-nitrocyclopropane With hydrogenchloride; zinc in methanol; water T=-5 - 0°C; 2: With ammonia in dichloromethane; water T=30°C; 0.25 h; 3: (R)-(-)-α-hydroxybenzeneacetic acid in methanol T=20 - 25°C;

1.1: hydrogenchloride; zinc / methanol / -5 - 0 °C 1.2: 0.25 h / 10 - 30 °C 2.1: methanol / 12 h / 20 - 25 °C View Scheme

1.1: hydrogenchloride; zinc / methanol / -5 - 0 °C 1.2: 0.25 h / 10 - 30 °C 2.1: methanol / 12 h / 20 - 25 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 25 °C 3.2: 3 h / 20 - 25 °C 4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -25 - -15 °C 4.2: 1.5 h / -25 - -15 °C 4.3: 0.08 h 5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 - 25 °C 6.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C 7.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C 8.1: iodine / acetone / 2 h / 25 - 60 °C 9.1: potassium carbonate / acetone / 20 h / 55 - 60 °C 10.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C 10.2: 25 - 30 °C / pH 10 11.1: formic acid / palladium 10 on activated carbon / 50 °C View Scheme