反应条件
1: N-(2,6-dichloro-4-pyridinyl)-2,2-dimethylpropanamide With n-butyllithium in tetrahydrofuran; hexanes T=-70 - -60°C; 1.5 h; Inert atmosphere; 2: 3-dimethylaminoacrylaldehyde in tetrahydrofuran; hexanes T=-70 - 20°C; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED; ATKINSON, Francis Louis; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander George Steven; WILSON, David Matthew
Patent: WO2011/134971 A1, 2011 ;
Location in patent: Page/Page column 12; 13; 53; 54 ;
WO 2011/134971 A1