22-羟基-33-O-叔-丁基二甲基硅烷基氧基-27-O-三甲基硅烷基-异-FK-506合成路线 （共 2 条）
反应条件
1: 69 percent / N-methyl-morpholine-N-oxide, tetrapropylammonium-perrhutenate / CH2Cl2 / 12 h / Ambient temperature; presence of 4 A mol sieve 2: 88 percent / 1 N HCl / acetonitrile / 0.5 h / Ambient temperature View Scheme
参考文献
Grassberger, Maximilian A.; Fehr, Theodor; Horvath, Amarylla; Schulz, Gerhard
Tetrahedron, 1992 , vol. 48, # 3 p. 413 - 430
反应条件
Multi-step reaction with 3 steps 1: 66 percent / tetramethylammonium triacetoxyborohydride / acetonitrile; acetic acid / 5 h / -5 - 0 °C2: 70 percent / 4-dimethylaminopyridine / dimethylformamide / 168 h / 50 °C3: 57 percent / 2,6-lutidine / CH2Cl2 / 0.5 h / -70 °C
参考文献
Grassberger, Maximilian A.; Fehr, Theodor; Horvath, Amarylla; Schulz, Gerhard Tetrahedron, 1992 , vol. 48, # 3 p. 413 - 430
