反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.67 h / 50 °C / |Cooling with ice 1.2: 4 h / 20 °C 2.1: 20 palladium(II) hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Astellas Pharma Inc.; SAMIZU, Kiyohiro; MASUDA, Naoyuki; IIKUBO, Kazuhiko; KOGANEMARU, Yohei; KAWANO, Noriyuki; OHMORI, Junya; MITANI, Yasuyuki; NI, Keni
Patent: EP2565194 A1, 2013 ;
