1: With 4-methyl-morpholine in tetrahydrofuran T=-15°C; 2: With isobutyl chloroformate in tetrahydrofuran T=-15°C; 3 h; 3: With sodium tetrahydroborate; water in tetrahydrofuran T=0 - 20°C; 0.333333 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/33451 A1, 2004 ;
Location in patent: Page 140 ;
1: With diisobutylaluminium hydride in dichloromethane T=-10 - 20°C; 2: With sodium hydrogencarbonate in dichloromethane; water Product distribution / selectivity;
