4-(2-吗啉-4-基-乙氧基)苯甲酸合成路线 （共 6 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 2: With hydrogenchloride in tetrahydrofuran; water pH=2;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 207-208 ;
反应条件
1: methyl 4-hydroxy-benzoate With potassium carbonate in DMF (N,N-dimethyl-formamide) T=100°C; 2: 2-(4-morpholino)ethyl chloride hydrochloride in DMF (N,N-dimethyl-formamide) T=100°C; 2 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/16611 A1, 2004 ;
Location in patent: Page 98 ;
WO 2004/016611 A1
反应条件
potassium hydroxide; potassium carbonate in N-methyl-acetamide; ice-water; ethanol; water
反应条件
cyclohexa-1,4-diene; Pearlman's catalist in methanol; ethyl acetate T=64°C; 1 h; Inert atmosphereSealed tube;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 4 p. 1774 - 1787
反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 60 °C 2.1: N,N-dimethyl-formamide / 20 °C 3.1: sodium hydroxide; water / methanol / 2 h / 40 °C 3.2: pH 4 / Acidic conditions View Scheme
反应条件
1.1: N,N-dimethyl-formamide / 20 °C 2.1: sodium hydroxide; water / methanol / 2 h / 40 °C 2.2: pH 4 / Acidic conditions View Scheme
