反应条件
Multi-step reaction with 7 steps 1: ethanol / 0.5 h / 45 - 53 °C / |Large scale2: potassium 2-methyl-2-butoxide; ethyl-α,α,α-trifluoroacetate / ethanol; toluene / 9 h / 60 - 63 °C / |Large scale3: potassium tert-butylate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 20 - 37 °C / |Large scale4: formamide; phosphoric acid / 120 °C5: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 2 h / 110 °C6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 58 °C / |Large scale7: sodium hydroxide / water / 6 h / 60 - 65 °C
参考文献
Shi, Zhongping; Kiau, Susanne; Lobben, Paul; Hynes Jr., John; Wu, Hong; Parlanti, Luca; Discordia, Robert; Doubleday, Wendel W.; Leftheris, Katerina; Dyckman, Alaric J.; Wrobleski, Stephen T.; Dambalas, Konstantinos; Tummala, Srinivas; Leung, Simon; Lo, Ehrlic Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1618 - 1625
