1: bromo-difluoroacetic acid,ethyl ester With chloro-trimethyl-silane; zinc in tetrahydrofuran T=20°C; 0.166667 h; 2: isoprene in tetrahydrofuran T=20°C; 3 h;

1.1: water; diethyl ether; methanol / |Reflux 2.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 0.17 h / 20 °C 2.2: 3 h / 20 °C View Scheme