2-羟基-5-溴吡啶合成路线

参考文献

WO2009/105500 A1, ;

Page/Page column 218-219 ;
WO 2009/105500 A1

参考文献

Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
Patent: US2010/331320 A1, 2010 ;
Location in patent: Page/Page column 78 ;

75-30-92-碘代丙烷+

13466-38-12-羟基-5-溴吡啶

851087-08-65-溴-1-异丙基吡啶-2(1H)-酮

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FORD, Rhonan; KINCHIN, Elizabeth; MATHER, Andrew; METE, Antonio; MILLICHIP, Ian; STANIER, Andrew Geoffrey
Patent: WO2011/154677 A1, 2011 ;
Location in patent: Page/Page column 103-104 ;
WO 2011/154677 A1

13466-38-12-羟基-5-溴吡啶

874959-68-95-溴-2-吡啶磺酰氯

参考文献

US2012/309796 A1, ;

13466-38-12-羟基-5-溴吡啶+

100-39-0溴化苄

83664-33-92-苄氧基-5-溴吡啶

参考文献

NOVARTIS AG; AUBERSON, Yves; BOCK, Mark Gary; BRAGA, Dario; CURZI, Marco; DODD, Stephanie Kay; GIAFFREDA, Stefano Luca; JIANG, Haiyang; KARPINSKI, Piotr; TROXLER, Thomas J.; WANG, Tielin; WANG, Xiaoyang; ZHANG, Xuechun
Patent: WO2014/13469 A1, 2014 ;
Location in patent: Page/Page column 37; 38 ;

13466-38-12-羟基-5-溴吡啶+

100-39-0溴化苄

83664-33-92-苄氧基-5-溴吡啶

参考文献

Pfizer Inc
Patent: US2005/187266 A1, 2005 ;

13466-38-12-羟基-5-溴吡啶+

74-88-4甲基碘

81971-39-35-溴-1-甲基-2(1H)-吡啶酮

参考文献

Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
Patent: US2010/331320 A1, 2010 ;
Location in patent: Page/Page column 56 ;

13466-38-12-羟基-5-溴吡啶

53939-30-35-溴-2-氯吡啶

参考文献

Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua
Molecules, 2012 , vol. 17, # 4 p. 4533 - 4544

13466-38-12-羟基-5-溴吡啶+

74-88-4甲基碘

13472-85-0

参考文献

Shiao, Min-Jen; Tarng, Kai-Yih
Heterocycles, 1990 , vol. 31, # 5 p. 819 - 824

13466-38-12-羟基-5-溴吡啶

1257553-79-9

参考文献

EUROSCREEN S.A.; HOVEYDA, Hamid; DUTHEUIL, Guillaume; EL BOUSMAQUI, Mohamed; BERNARD, Jerome
Patent: WO2011/151434 A1, 2011 ;
WO 2011/151434 A1