2-羟基-5-溴吡啶合成路线

参考文献

Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin; Spear, Kerry L.
Patent: US2010/204214 A1, 2010 ;
Location in patent: Page/Page column 117 ;

13466-38-12-羟基-5-溴吡啶+

411235-57-9环丙基硼酸

1193334-67-6

参考文献

Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
Patent: US2010/331320 A1, 2010 ;
Location in patent: Page/Page column 37; 38 ;

13466-38-12-羟基-5-溴吡啶+

95353-04-1

参考文献

Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
Patent: US2010/331320 A1, 2010 ;
Location in patent: Page/Page column 97 ;

623-73-4重氮乙酸乙酯+

13466-38-12-羟基-5-溴吡啶

79674-66-12-[(5-溴-2-吡啶)氧基]乙酸

参考文献

Cava; Bhattacharyya
Journal of Organic Chemistry, 1958 , vol. 23, p. 1614

13466-38-12-羟基-5-溴吡啶

431942-30-2

参考文献

Van De Poel, Herve; Guillaumet, Gerald; Viaud-Massuard, Marie-Claude
Heterocycles, 2002 , vol. 57, # 1 p. 55 - 71

13466-38-12-羟基-5-溴吡啶+

74-88-4甲基碘

51417-13-15-溴-1,3-二甲基-2-吡啶酮

参考文献

INTELLKINE, LLC; INFINITY PHARMACEUTICALS, INC.; CASTRO, Alfredo C.; EVANS, Catherine A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel A.; TREMBLAY, Martin R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina
Patent: US2013/53362 A1, 2013 ;
Location in patent: Paragraph 1001; 1002 ;

13466-38-12-羟基-5-溴吡啶+

75-03-6碘乙烷

63785-87-55-溴-1-乙基吡啶-2(1H)-酮

参考文献

TAKEDA PHARMACEUTICAL COMPANY LIMITED; BRESSI, Jerome, C.; CHU, Shaosong; ERICKSON, Philip; KOMANDLA, Mallareddy; KWOK, Lily; LAWSON, John, D.; STAFFORD, Jeffrey, A.; WALLACE, Michael, B.; ZHANG, Zhiyuan; DAS, Sanjib
Patent: WO2010/19899 A1, 2010 ;
Location in patent: Page/Page column 214 ;

13466-38-12-羟基-5-溴吡啶+

74-96-4溴乙烷

63785-87-55-溴-1-乙基吡啶-2(1H)-酮

参考文献

Saidova, F. M.; Binchkauskas, V. Sh.; Khorev, S. G.; Enikeev, E. Ya.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 353 - 357
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 413 - 417