toluene-4-sulfonic acid in dimethyl sulfoxide T=100°C; 3 h;

<b>Multi-step reaction with 4 steps<br /> </b>1: 30 percent H₂O₂, KOH / methanol / Ambient temperature<br />2: 1.) t-BuOK / 1.) THF, r.t., 2.) r.t.<br />3: 94 percent / lithium diisopropylamide / tetrahydrofuran / 1.) -60 deg C, 2.) 0 deg C<br />4: 1.) oxalyl dichloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2.) -60 deg C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 94 percent / lithium diisopropylamide / tetrahydrofuran / 1.) -60 deg C, 2.) 0 deg C<br />2: 1.) oxalyl dichloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2.) -60 deg C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: LiClO₄*3H₂O, tributylphosphine oxide / toluene / Heating<br />2: 30 percent H₂O₂, KOH / methanol / Ambient temperature<br />3: 1.) t-BuOK / 1.) THF, r.t., 2.) r.t.<br />4: 94 percent / lithium diisopropylamide / tetrahydrofuran / 1.) -60 deg C, 2.) 0 deg C<br />5: 1.) oxalyl dichloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2.) -60 deg C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1361988', constants.ctx, '0')">oxalyl dichloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506008', constants.ctx, '0')">dimethyl sulfoxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a> <br />&nbsp;1.) CH₂Cl₂, -60 deg C, 2.) -60 deg C;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: 1.) lithium diisopropylamide / 1.) THF, -60 deg C, 2.) -60 deg C<br />2: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / Ambient temperature<br />3: LiClO₄*3H₂O, tributylphosphine oxide / toluene / Heating<br />4: 30 percent H₂O₂, KOH / methanol / Ambient temperature<br />5: 1.) t-BuOK / 1.) THF, r.t., 2.) r.t.<br />6: 94 percent / lithium diisopropylamide / tetrahydrofuran / 1.) -60 deg C, 2.) 0 deg C<br />7: 1.) oxalyl dichloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2.) -60 deg C<br /> <br /> &nbsp;