3,5-二溴-2-羟基嘧啶合成路线 （共 11 条）
反应条件
N-bromosuccinmide in tetrachloromethane T=20°C; 48 h;
参考文献
Canibano; Rodriguez; Santos; Sanz-Tejedor; Carreno; Gonzalez; Garcia-Ruano
Synthesis, 2001 , # 14 p. 2175 - 2179
反应条件
sulfuric acid; sodium nitrite Diazotization.Erwaermen der Diazoniumsalz-Loesung;
参考文献
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 50, p. 489
Chem. Zentralbl., , vol. 94, # III p. 1021
参考文献
Justus Liebigs Annalen der Chemie, , vol. 480, p. 179
反应条件
1: sulfuric acid; bromine 2: diluted sulfuric acid; sodium nitrite / Diazotization.Erwaermen der Diazoniumsalz-Loesung View Scheme
参考文献
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 50, p. 489
Chem. Zentralbl., , vol. 94, # III p. 1021
反应条件
hydrogenchloride; sodium nitrite
参考文献
Chemische Berichte, , vol. 66, p. 364,368
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 70, p. 182,190
反应条件
trichlorophosphate T=140°C; 2 h; Autoclaveneat (no solvent);
参考文献
Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua
Molecules, 2012 , vol. 17, # 4 p. 4533 - 4544
反应条件
silver carbonate in benzene T=40 - 50°C; 24 h;
参考文献
Shiao, Min-Jen; Tarng, Kai-Yih
Heterocycles, 1990 , vol. 31, # 5 p. 819 - 824
反应条件
silver carbonate in benzene T=40 - 50°C; 24 h;
参考文献
Shiao, Min-Jen; Tarng, Kai-Yih
Heterocycles, 1990 , vol. 31, # 5 p. 819 - 824
反应条件
1: 1H-3,5-dibromopyridine-2-one With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
CGI PHARMACEUTICALS, INC.
Patent: WO2008/33858 A2, 2008 ;
Location in patent: Page/Page column 127-128 ;
WO 2008/033858 A2
