1: With n-butyllithium in tetrahydrofuran; hexane; toluene T=-50°C; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane; toluene T=-50 - -15°C; 3: With sodium hydroxide in tetrahydrofuran; hexane; toluene
参考文献
Denton, Travis T.; Zhang, Xiaodong; Cashman, John R.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 224 - 239
1: 2-methoxy-5-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - -20°C; 3: With hydrogenchloride; water in tetrahydrofuran; hexane pH=5;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/68436 A1, 2005 ;
Location in patent: Page/Page column 26 ;