trifluoroacetic acid in dichloromethane T=0 - 20°C; Inert atmosphere;

1: 2-hydroxy-1,3-isoindolinedione With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.166667 h; Inert atmosphere; 2: monobromoacetic acid in N,N-dimethyl-formamide T=0 - 20°C; Inert atmosphere;

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 - 50 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 1.33 h / 0 °C View Scheme