N-Boc-2-氨甲基吡啶合成路线 （共 6 条）
反应条件
in dichloromethane T=0 - 20°C;
参考文献
Benoist, Eric; Coulais, Yvon; Almant, Mehdi; Kovensky, Jose; Moreau, Vincent; Lesur, David; Artigau, Marine; Picard, Claude; Galaup, Chantal; Gouin, Sebastien G.
Carbohydrate Research, 2011 , vol. 346, # 1 p. 26 - 34
反应条件
C45H59ClNPPd; potassium carbonate in water; tert-butyl alcohol T=85°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2013 , vol. 15, # 10 p. 2534 - 2537
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in water; toluene T=85°C; Suzuki-Miyaura cross-coupling reaction; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2011 , vol. 13, # 15 p. 3956 - 3959
反应条件
in 2-Pyridinylmethylamine; dichloromethane
参考文献
Abbott Laboratories
Patent: US5142056 A1, 1992 ;
US 5142056 A
反应条件
platinum(IV) oxide; hydrogen in ethanol; acetic acid P=3102.9 Torr;
参考文献
Shearer, Barry G.; Sullivan, James P.; Carter, J. Paul; Mathew, Rose M.; Waid, Phillip; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2928 - 2931
反应条件
1: 1.) sodium hydride / 1.) THF, 0 deg C, 15 min, 2.) THF, RT, 2 h 2: HCl / dioxane / 0.5 h / 40 °C View Scheme
参考文献
Kempf, Dale J.; Codacovi, Lynnmarie; Wang, Xiu Chun; Kohlbrenner, William E.; Wideburg, Norman E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 320 - 330
