(1R)-4-[1-氨基乙基]苯酚合成路线 (共 4 条)
反应条件
(R)-alanine; Mycobacterium vanbaalenii (R)-selective ω-transaminase in water T=37°C; pH=7.5; Enzymatic reaction; Reagent/catalyst; enantioselective reaction;
参考文献
Shin, Giyoung; Mathew, Sam; Shon, Minsu; Kim, Byung-Gee; Yun, Hyungdon
Chemical Communications, 2013 , vol. 49, # 77 p. 8629 - 8631
反应条件
[14C]-2-Ketoglutaric acid; Polaromonas sp. JS666 (S)-selective ω-transaminase; tris(hydroxymethyl)methylamine hydrochloride in water T=37°C; pH=7.5; Enzymatic reaction; enantioselective reaction;
参考文献
Shin, Giyoung; Mathew, Sam; Shon, Minsu; Kim, Byung-Gee; Yun, Hyungdon
Chemical Communications, 2013 , vol. 49, # 77 p. 8629 - 8631
反应条件
1: Polaromonas sp. JS666 (S)-selective ω-transaminase; [14C]-2-Ketoglutaric acid; tris(hydroxymethyl)methylamine hydrochloride / water / 37 °C / pH 7.5 / |Enzymatic reaction 2: Mycobacterium vanbaalenii (R)-selective ω-transaminase; (R)-alanine / water / 37 °C / pH 7.5 / |Enzymatic reaction View Scheme
参考文献
Shin, Giyoung; Mathew, Sam; Shon, Minsu; Kim, Byung-Gee; Yun, Hyungdon
Chemical Communications, 2013 , vol. 49, # 77 p. 8629 - 8631
反应条件
hydrogen; acetic acid; platinum(IV) oxide in methanol P=3102.97 Torr; 18 h; Product distribution / selectivity;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/79346 A1, 2008 ;
Location in patent: Page/Page column 66; 67 ;
WO 2008/079346 A1