(4-碘苯基乙炔)三甲基硅烷合成路线 （共 30 条）
反应条件
1: With hydrogenchloride; sodium nitrite T=0 - 5°C; 0.75 h; 2: With potassium iodide in dichloromethane; water T=20°C; 4 h; Further stages.;
参考文献
Aujard; Baltaze; Baudin; Cogne; Ferrage; Jullien; Perez; Prevost; Lin Mao Qian; Ruel
Journal of the American Chemical Society, 2001 , vol. 123, # 34 p. 8177 - 8188
反应条件
iodine; tert.-butyl lithium T=-78°C;
参考文献
Blakskjaer, Peter; Gothelf, Kurt V.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 18 p. 3442 - 3447
反应条件
copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran 36 h; Ambient temperature;
参考文献
Yao, Yuxing; Tour, James M.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 1968 - 1971
反应条件
1.1: 6 M HCl / acetonitrile / 0.25 h / 70 °C 1.2: aq. sodium nitrite / H2O; acetonitrile / 0.25 h / 15 °C 1.3: 94 percent / potassium carbonate / acetonitrile; H2O / 0.17 h / cooling 2.1: 95 percent / copper iodide; bis(triphenylphosphine)palladium(II) chloride; triethylamine / 3 h / 30 °C 3.1: 86 percent / methyl iodide / 96 h / 110 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 14 p. 2447 - 2461
反应条件
methyl iodide T=115°C; 24 h;
参考文献
Wautelet, Pascale; Le Moigne, Jacques; Videva, Vladimira; Turek, Philippe
Journal of Organic Chemistry, 2003 , vol. 68, # 21 p. 8025 - 8036
反应条件
1.1: 95 percent / CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran 2.1: n-BuLi / diethyl ether 2.2: 90 percent / I2 / diethyl ether View Scheme
参考文献
Chemical Communications, , # 38 p. 4786 - 4788
反应条件
1: 82 percent / Et3N; PPh3; CuI / Pd(OAc)2 / 20 °C 2: 87 percent / tBuONO; BF3*Et2O / tetrahydrofuran / 1 h / -20 - 5 °C 3: 67 percent / aq. KI / acetone / 0 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 7, # 21 p. 4706 - 4714
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); potassium carbonate Sonogashira coupling; 17 h; Neat (no solvent);
参考文献
Green Chemistry, , vol. 11, # 11 p. 1821 - 1825
反应条件
1.1: hydrochloric acid; NaNO2 / H2O / 0.5 h / cooling 1.2: 91 percent / K2CO3 / H2O / 0.5 h / 0 - 20 °C 2.1: 76 percent / TPP; Cu(OAc)2; Et3N / PdCl2 / 6 h / Heating 3.1: 97 percent / MeI / 24 h / 115 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 21 p. 8025 - 8036
参考文献
Moore, Jeffrey S.; Weinstein, Edward J.; Wu, Ziyan
Tetrahedron Letters, 1991 , vol. 32, # 22 p. 2465 - 2466
