2-(二甲基氨基羰基)乙基硼酸合成路线 （共 4 条）
反应条件
methanol; [Pd2(μ-C9H7NPPh2)(μ-O2CCH3)]2; water; caesium carbonate in tetrahydrofuran T=25°C; 6 h; Inert atmosphere;
参考文献
Bonet, Amadeu; Gulyas, Henrik; Koshevoy, Igor O.; Estevan, Francisco; Sanau, Mercedes; Ubeda, M. Angeles; Fernandez, Elena
Chemistry - A European Journal, 2010 , vol. 16, # 21 p. 6382 - 6390
反应条件
1: N,N-dimethyl-2-propenamide With cupric(II) carbonate; 2-amino-2-deoxyglucose hydrochloride; sodium hydroxide in water T=20°C; 1.25 h; 2: N,N-dimethyl-2-propenamide in water T=60°C; 20 h;
参考文献
LEK Pharmaceuticals d.d.; The designation of the inventor has not yet been filed
Patent: EP2647639 A1, 2013 ;
Location in patent: Paragraph 0092; 0093 ;
反应条件
1: 4,8-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,6,2-dioxazaborocane With copper(l) chloride in dichloromethane 0.166667 h; Inert atmosphere; 2: N,N-dimethyl-2-propenamide in methanol; dichloromethane T=0 - 20°C; 48 h; Inert atmosphere;
参考文献
Gao, Ming; Thorpe, Steven B.; Kleeberg, Christian; Slebodnick, Carla; Marder, Todd B.; Santos, Webster L.
Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 3997 - 4007
反应条件
2,8,9-trimethyl-1-phospha-2,5,8,9-tetraazabicyclo[3.3.3]undecane in tetrahydrofuran T=70°C; 24 h; Inert atmosphere;
参考文献
Pubill-Ulldemolins, Cristina; Bonet, Amadeu; Bo, Carles; Gulyas, Henrik; Fernandez, Elena
Chemistry - A European Journal, 2012 , vol. 18, # 4 p. 1121 - 1126
