(alphaS)-alpha-(1-甲基乙基)苯乙酸合成路线 （共 16 条）
反应条件
sulfuric acid in water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/14575 A1, 2005 ;
Location in patent: Page/Page column 20 ;
WO 2005/014575 A1
反应条件
hydrogen; (R)-N-methyl-N-lt;2-(4-morpholino)ethylgt;-lt;1-(S)-1',2-bis(diphenylphosphino)ferrocenylgt;ethylamine in tetrahydrofuran; methanol P=38000 Torr; 30 h; Ambient temperature; Yield given;
参考文献
Journal of the American Chemical Society, , vol. 109, # 25 p. 7876 - 7878
反应条件
Jone's reagent; ozone in acetone T=-78°C;
参考文献
Spino; Beaulieu; Lafreniere
Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7091 - 7097
参考文献
Tanaka, Fujie; Node, Manabu; Tanaka, Kiyoshi; Mizuchi, Maki; Hosoi, Shinzo; Nakayama, Masayo; Taga, Tooru; Fuji, Kaoru
Journal of the American Chemical Society, 1995 , vol. 117, # 49 p. 12159 - 12171
反应条件
1: phenylacetic acid With n-butyllithium; (R,R)-N,N'-di-(1-phenyl-2-(1-piperidinyl)ethyl)-1,3-propanediamine in tetrahydrofuran; hexanes T=0°C; Inert atmosphere; 2: 2-iodo-propane in tetrahydrofuran; hexanes T=-78°C; 0.333333 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Stivala, Craig E.; Zakarian, Armen
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 11936 - 11939
参考文献
Tetrahedron, , vol. 27, p. 1173 - 1184
反应条件
silver tetrafluoroborate; (S)-cyclohexyl-BINAP; hydrogen; triethylamine; rhodium(I) chloride in methanol T=25°C; P=38000 Torr; 24 h; asymmetric hydrogenation, various substrates and chiral ligands; Product distribution;
参考文献
Bioscience, Biotechnology, and Biochemistry, , vol. 58, # 11 p. 2071 - 2072
反应条件
potassium phosphate buffer; Rhodococcus sp. AJ270 T=30°C; Hydrolysis; pH=7.0; 120 h;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 5 p. 1123 - 1135
反应条件
(1R,2S)-1-amino-benz[f]indan-2-ol in ethanol; water 13 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 22 p. 7436 - 7441
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 25 - 40 °C / |Inert atmosphere; |Schlenk technique 1.2: |Cooling with ice 2.1: triethylamine; hydrogen; (Sa)-[(C8H12)Ir(P(3,5-(tert-butyl)2C6H3)2C8H7CC8H7C3NOH4)][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate] / methanol / 20 h / 60 °C / 4560.31 Torr / |Autoclave; |Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 15, # 14 p. 3722 - 3725
